Severe hyponatremia followed by extrapontine myelinolysis

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Extrapontine myelinolysis in a patient following correction of hyponatremia.

From the Department of Neurology, Cheng-Kung University Hospital, Tainan, Taiwan. Received June 4, 2007. Revised June 20, 2007. Accepted July 9, 2007. Reprint requests and correspondence to: Chin-Wei Huang, MD. Department of Neurology, National Cheng Kung University Hospital, No. 138, Sheng-Li Road, Tainan, Taiwan. E-mail: [email protected] A 76 years old woman was referred to our emerge...

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Reversible Cerebellar Ataxia Related to Extrapontine Myelinolysis without Hyponatremia after Cisplatin-Based Chemotherapy for Cholangiocarcinoma

A 60-year-old woman presented with cerebellar signs including dysarthria and ataxia, after intravenous infusion of cisplatin-based chemotherapy. Several blood tests showed mild neutropenia, normocytic normochromic anemia, but no evidence of a marked hyponatremia. Brain magnetic resonance imaging with diffusion-weighted sequences showed hyper-intense signal abnormalities in the extrapontine regi...

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Neuropsychological Findings of Extrapontine Myelinolysis without Central Pontine Myelinolysis

Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are well recognized syndromes related to the rapid correction of hyponatremia, which are reported to show brain stem signs and various movement disorders. Cognitive dysfunction and neuropsychological findings, however, have seldom been reported. Cognitive manifestations in osmotic myelinolysis may have been underestimated du...

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Dystonia in central pontine myelinolysis without evidence of extrapontine myelinolysis.

A 44-year-old female is described who developed persistent upper extremity and orolingual dystonia several weeks after suspected onset of central pontine myelinolysis (CPM), later confirmed by characteristic pontine lesions on MRI. No foci of the extrapontine myelinolysis were evident. This case confirms that dystonia may be a late and persistent sequela of CPM and may occur in the absence of v...

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Isolated extrapontine myelinolysis of osmotic demyelination syndrome.

The osmotic demyelination syndrome (ODS) has been identified as a complication of the rapid correction of hyponatremia for decades (King and Rosner, 2010). However, in recent years, a variety of other medical conditions have been associated with the development of ODS, independent of changes in serum sodium which cause a rapid changes in osmolality of the interstitial (extracellular) compartmen...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2006

ISSN: 0085-2538

DOI: 10.1038/sj.ki.5000173